Saturday, May 23, 2009

Mineralizing microangiopathy

Lateral radiograph of 14 year old boy who underwent radiotherapy and chemotherapy for right frontal glioma shows linear tram tack calcification in the frontal region.

CT scan of the same patient showed caorse gyral patternn calcification in the roght frontal region with white matter edema in bilateral frontal lobes.

Mineralizing microangiopathy, a distinctive histopathologic process involving the microvasculature of the central nervous system (CNS), is usually seen following combined radiation and chemotherapy for the treatment of CNS neoplasms in childhood. It represents dystrophic calcification within the brain substance, predominantly involves the basal ganglia and subcortical white matter and is well shown by CT. CT typically demonstrates calcification within the basal ganglia and subcortical white matter. MRI, although less sensitive than CT to calcification, The areas of calcification may give paradoxically increased signal on T1-weighted MRI due to a surface-relaxation mechanism, and decreased signal on T2-weighted images. This should be differentiated from Sturge weber syndrome by the clinical presentation and other imaging findings.

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